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Volumetric contrast-enhanced ultrasound for characterizing tumor vascularity: Preliminary studies in an animal model

This paper appears in:
Ultrasonics Symposium (IUS), 2011 IEEE International
Date of Conference: 18-21 Oct. 2011
Author(s): Hoyt, K.
Dept. of Radiol., Univ. of Alabama at Birmingham, Birmingham, AL, USA
Sorace, A.G.
Page(s): 1292 - 1295
Product Type: Conference Publications

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Abstract

This paper describes a volumetric strategy for characterization of tumor blood flow using microbubble (MB) contrast agents and ultrasound (US) imaging. Volumetric contrast-enhanced US (VCEUS) imaging was implemented on a SONIX RP US system (Ultrasonix Medical Corp) equipped with a broadband 4DL14-5/38 probe. Acquisition of VCEUS data was achieved at a volume rate of 1 Hz using a MB sensitive harmonic imaging mode. Following MB infusion, custom Matlab programs were used to compute MB time-intensity curve-specific parameters: blood volume (IPK), transit time (T1/2PK), flow rate (SPK), and tumor perfusion (AUC). Using a xenograft model of human breast cancer, it is shown that millimeter-sized deviations in transducer positioning can have profound implications on US-based blood flow estimators with errors ranging from 6.4 to 40.3% and dependent on both degree of misalignment and particular blood flow estimator. These errors indicate that VCEUS imaging should be considered in tumor analyses because they incorporate the entire mass and not just a representative planar cross-section.

Index Terms

  • IEEE Terms

    Animals , Blood flow , Fluid flow measurement , Imaging , Transducers , Tumors , Ultrasonic imaging

  • INSPEC
    • Controlled Indexing

      biological organs , biomedical ultrasonics , bubbles , cancer , data acquisition , gynaecology , haemodynamics , haemorheology , mathematics computing , medical image processing , tumours , ultrasonic transducers

    • Non Controlled Indexing

      MB sensitive harmonic imaging mode , MB time-intensity curve-specific parameters , SONIX RP US system , US- based blood flow estimators , Ultrasonix Medical Corp , VCEUS data acquisition , VCEUS imaging , animal model , blood volume , broadband 4DL14-5-38 probe , custom Matlab programs , frequency 1 Hz , human breast cancer , image processing , microbubble contrast agents , millimeter-sized deviations , transducer positioning , transit time , tumor blood flow rate , tumor perfusion , tumor vascularity , volumetric contrast-enhanced US imaging , volumetric contrast-enhanced ultrasound imaging , volumetric strategy , xenograft model

  • Author Keywords

    contrast agent , microbubble , tumor perfusion , ultrasound , volumetric imaging

 
Topic(s) :   Bioengineering ; Communication, Networking & Broadcasting ; Components, Circuits, Devices & Systems ; Computing & Processing (Hardware/Software) ; Signal Processing & Analysis
Conference Location :  Orlando, FL
ISSN :  1948-5719
Print ISBN: 978-1-4577-1253-1
INSPEC Accession Number: 12968842
Digital Object Identifier :  10.1109/ULTSYM.2011.0319
Date of Current Version :   03 September 2012
Issue Date :   18-21 Oct. 2011






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